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Genetics Home Reference: your guide to understanding genetic conditions
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Small miscellaneous ncRNAs gene family

Reviewed March 2014

What are the small miscellaneous ncRNAs genes?

Genes in this gene family provide instructions for making molecules called small miscellaneous noncoding RNAs. Noncoding RNAs are a particular type of RNA, which is a chemical cousin of DNA.

The most common form of RNA (called messenger RNA) is considered protein-coding RNA, because it acts as the blueprint for making proteins. Noncoding RNAs, however, do not carry (encode) information for producing proteins, although they do have other important functions in cells.

There are several types of noncoding RNAs. For example, transfer RNAs help assemble protein building blocks (amino acids) into functioning proteins. Small interfering RNAs suppress the activity (expression) of specific genes. The genes in the small miscellaneous noncoding RNA family provide instructions for making RNA molecules that have not been classified into one of the other types. For example, the TERC gene provides instructions for making an RNA molecule that is involved in the maintenance of structures called telomeres, which are composed of repeated segments of DNA found at the ends of chromosomes.

Which genes are included in the small miscellaneous ncRNAs gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the small miscellaneous ncRNAs family (http://www.genenames.org/rna/MISCRNA).

Genetics Home Reference summarizes the normal function and health implications of these members of the small miscellaneous ncRNAs gene family: RMRP and TERC.

What conditions are related to genes in the small miscellaneous ncRNAs gene family?

Genetics Home Reference includes these conditions related to genes in the small miscellaneous ncRNAs gene family:

  • cartilage-hair hypoplasia
  • dyskeratosis congenita
  • idiopathic pulmonary fibrosis

Where can I find additional information about the small miscellaneous ncRNAs gene family?

You may find the following resources about the small miscellaneous ncRNAs gene family helpful.

  • Center for RNA Interference and Non-Coding RNAs (http://www.mdanderson.org/education-and-research/research-at-md-anderson/early-detection-and-treatment/centers/center-for-rna-interference-and-non-coding-rnas/index.html) (MD Anderson Cancer Center)

What glossary definitions help with understanding the small miscellaneous ncRNAs gene family?

acids ; DNA ; gene ; messenger RNA ; molecule ; protein ; RNA

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

These sources were used to develop the Genetics Home Reference summary for the small miscellaneous ncRNAs gene family.

  • Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29. Review. (http://www.ncbi.nlm.nih.gov/pubmed/16651366?dopt=Abstract)
  • Taft RJ, Pang KC, Mercer TR, Dinger M, Mattick JS. Non-coding RNAs: regulators of disease. J Pathol. 2010 Jan;220(2):126-39. doi: 10.1002/path.2638. Review. (http://www.ncbi.nlm.nih.gov/pubmed/19882673?dopt=Abstract)
  • Brosnan CA, Voinnet O. The long and the short of noncoding RNAs. Curr Opin Cell Biol. 2009 Jun;21(3):416-25. doi: 10.1016/j.ceb.2009.04.001. Epub 2009 May 15. Review. (http://www.ncbi.nlm.nih.gov/pubmed/19447594?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: March 2014
Published: November 24, 2014