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Genetics Home Reference: your guide to understanding genetic conditions
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THAP domain containing gene family

Reviewed November 2013

What are the THAP domain containing genes?

The THAP domain containing family includes genes that provide instructions for proteins that contain a region called a THAP domain. The THAP domain is a type of zinc finger domain, which are regions that include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). This configuration makes proteins containing these domains very stable and enables them to attach (bind) firmly to other molecules.

Proteins in the THAP domain containing family target and bind to particular sequences of DNA building blocks (nucleotides). By binding to particular regions of DNA, THAP proteins act as transcription factors, which means they regulate the activity of other genes. In doing so, they play roles in cellular processes such as growth and division (proliferation), replication (the cell cycle), and controlled cell death (apoptosis). In addition, some proteins in this family are involved in the formation of blood vessels (angiogenesis).

Genetic changes that affect proteins produced from genes in this family have been linked to cancer and movement problems. The variety of these proteins' roles suggests that they might also be involved in additional types of disorders.

Which genes are included in the THAP domain containing gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the THAP domain containing family (http://www.genenames.org/genefamilies/THAP).

Genetics Home Reference summarizes the normal function and health implications of this member of the THAP domain containing gene family: THAP1.

What conditions are related to genes in the THAP domain containing gene family?

Genetics Home Reference includes these conditions related to genes in the THAP domain containing gene family:

  • dystonia 6

Where can I find additional information about the THAP domain containing gene family?

You may find the following resources about the THAP domain containing gene family helpful.

  • Molecular Biology of the Cell (fourth edition, 2002): There Are Several Types of DNA-binding Zinc Finger Motifs (http://www.ncbi.nlm.nih.gov/books/NBK26806/)

What glossary definitions help with understanding the THAP domain containing gene family?

acids ; angiogenesis ; apoptosis ; cancer ; cell ; cell cycle ; DNA ; domain ; ions ; proliferation ; protein ; transcription ; zinc finger domain

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

These sources were used to develop the Genetics Home Reference summary for the THAP domain containing gene family.

  • Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem Sci. 2003 Feb;28(2):66-9. (http://www.ncbi.nlm.nih.gov/pubmed/12575992?dopt=Abstract)
  • Quesneville H, Nouaud D, Anxolabehere D. Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the P-transposable element. Mol Biol Evol. 2005 Mar;22(3):741-6. Epub 2004 Dec 1. Erratum in: Mol Biol Evol. 2005 Apr;22(4):1160. (http://www.ncbi.nlm.nih.gov/pubmed/15574804?dopt=Abstract)
  • Sabogal A, Lyubimov AY, Corn JE, Berger JM, Rio DC. THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. Nat Struct Mol Biol. 2010 Jan;17(1):117-23. doi: 10.1038/nsmb.1742. Epub 2009 Dec 13. (http://www.ncbi.nlm.nih.gov/pubmed/20010837?dopt=Abstract)
  • Campagne S, Saurel O, Gervais V, Milon A. Structural determinants of specific DNA-recognition by the THAP zinc finger. Nucleic Acids Res. 2010 Jun;38(10):3466-76. doi: 10.1093/nar/gkq053. Epub 2010 Feb 9. (http://www.ncbi.nlm.nih.gov/pubmed/20144952?dopt=Abstract)
  • Gervais V, Campagne S, Durand J, Muller I, Milon A. NMR studies of a new family of DNA binding proteins: the THAP proteins. J Biomol NMR. 2013 May;56(1):3-15. doi: 10.1007/s10858-012-9699-1. Epub 2013 Jan 11. Review. (http://www.ncbi.nlm.nih.gov/pubmed/23306615?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: November 2013
Published: December 16, 2014