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Genes in the ZFYVE family provide instructions for making proteins that contain a short region called an FYVE zinc finger. This region includes a specific pattern of protein building blocks (amino acids) and two charged atoms of zinc (zinc ions). FYVE zinc fingers direct the proteins that contain them to various compartments within the cell by attaching (binding) to a substance on the surface of these compartments called phosphatidylinositol-3-phosphate (PI3P).
The FYVE zinc finger was named after the initials of the first four proteins that were found to contain this region: Fab1, YOTB, Vac1, and EEA1. There are now at least 60 proteins that are known to contain an FYVE zinc finger.
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the ZFYVE family (http://www.genenames.org/genefamily/zfyve.php).
Genetics Home Reference summarizes the normal function and health implications of these members of the ZFYVE gene family: FGD1, FGD4, and ZFYVE26.
Genetics Home Reference includes these conditions related to genes in the ZFYVE gene family:
You may find the following resources about the ZFYVE gene family helpful.
acids ; cell ; domain ; ions ; pH ; phosphate ; protein
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
These sources were used to develop the Genetics Home Reference summary for the ZFYVE gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.