Skip Navigation
Genetics Home Reference: your guide to understanding genetic conditions
http://ghr.nlm.nih.gov/     A service of the U.S. National Library of Medicine®

ZMYM gene family

Reviewed July 2013

What are the ZMYM genes?

Genes in the ZMYM family provide instructions for making proteins known as MYM-type zinc finger proteins. This family is a subset of a much larger group of zinc finger proteins, which are involved in many cellular functions.

Zinc finger proteins contain one or more short regions called zinc finger domains. These regions include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). This configuration makes zinc finger proteins very stable and enables them to attach (bind) firmly to other molecules.

Little is known about the function of MYM-type zinc finger proteins. Unlike many other zinc finger proteins, proteins in this family do not appear to bind to DNA. Instead, studies suggest that they help regulate interactions between other proteins. As part of protein complexes, MYM-type zinc finger proteins may be involved in regulating the activity of particular genes or repairing damaged DNA.

Which genes are included in the ZMYM gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the ZMYM family (http://www.genenames.org/genefamilies/ZMYM).

Genetics Home Reference summarizes the normal function and health implications of this member of the ZMYM gene family: ZMYM2.

What conditions are related to genes in the ZMYM gene family?

Genetics Home Reference includes these conditions related to genes in the ZMYM gene family:

  • 8p11 myeloproliferative syndrome

Where can I find additional information about the ZMYM gene family?

You may find the following resources about the ZMYM gene family helpful.

  • RCSB PDB-101: Zinc Fingers Protein Data Bank (http://www.rcsb.org/pdb/101/motm.do?momID=87)

What glossary definitions help with understanding the ZMYM gene family?

acids ; DNA ; ions ; protein

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

These sources were used to develop the Genetics Home Reference summary for the ZMYM gene family.

  • Interpro: Zinc Finger, MYM-type (http://www.ebi.ac.uk/interpro/entry/IPR010507)
  • Gocke CB, Yu H. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One. 2008 Sep 22;3(9):e3255. doi: 10.1371/journal.pone.0003255. (http://www.ncbi.nlm.nih.gov/pubmed/18806873?dopt=Abstract)
  • Sohal J, Reiter A, Goldman JM, Cross NC. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11-->q12. Cytogenet Cell Genet. 2000;89(1-2):24-8. (http://www.ncbi.nlm.nih.gov/pubmed/10894931?dopt=Abstract)
  • Pastorcic M, Das HK. Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM. Brain Res. 2007 Jan 12;1128(1):21-32. Epub 2006 Nov 28. (http://www.ncbi.nlm.nih.gov/pubmed/17126306?dopt=Abstract)
  • Molecular Cell Biology (fourth edition, 2000): Zinc-Finger Proteins (http://www.ncbi.nlm.nih.gov/books/NBK21572/)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: July 2013
Published: December 22, 2014