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Genes in the ZMYND family provide instructions for making proteins known as MYND-type zinc finger proteins. This family is a subset of a much larger group of zinc finger proteins, which are involved in many cellular functions.
Zinc finger proteins contain one or more short regions called zinc finger domains. These regions include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). Specifically, the MYND domain consists of an amino acid cluster of seven cysteines and one histidine that fold around two zinc ions. This configuration stabilizes the protein and allows it to attach (bind) to other molecules.
Little is known about the function of MYND-type zinc finger proteins. Unlike many other zinc finger proteins, proteins in this family do not appear to bind to DNA. Instead, studies suggest that they help regulate interactions between other proteins. Proteins that partner with MYND-type zinc finger proteins help regulate gene activity and play important roles in normal development.
The MYND domain was named based on the first three proteins that were found to contain this region: myeloid translocation protein 8, Nervy, and DEAF-1. There are now more than 80 proteins known to contain the MYND domain.
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the ZMYND family (http://www.genenames.org/genefamily/zmynd.php).
Genetics Home Reference summarizes the normal function and health implications of these members of the ZMYND gene family: EGLN1 and RUNX1T1.
Genetics Home Reference includes these conditions related to genes in the ZMYND gene family:
You may find the following resources about the ZMYND gene family helpful.
acids ; amino acid ; DNA ; domain ; gene ; histidine ; hypoxia ; ions ; myeloid ; protein ; transcription ; transcription factor ; translocation
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
These sources were used to develop the Genetics Home Reference summary for the ZMYND gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.