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Genetics Home Reference: your guide to understanding genetic conditions
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ZMYND gene family

Reviewed August 2012

What are the ZMYND genes?

Genes in the ZMYND family provide instructions for making proteins known as MYND-type zinc finger proteins. This family is a subset of a much larger group of zinc finger proteins, which are involved in many cellular functions.

Zinc finger proteins contain one or more short regions called zinc finger domains. These regions include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). Specifically, the MYND domain consists of an amino acid cluster of seven cysteines and one histidine that fold around two zinc ions. This configuration stabilizes the protein and allows it to attach (bind) to other molecules.

Little is known about the function of MYND-type zinc finger proteins. Unlike many other zinc finger proteins, proteins in this family do not appear to bind to DNA. Instead, studies suggest that they help regulate interactions between other proteins. Proteins that partner with MYND-type zinc finger proteins help regulate gene activity and play important roles in normal development.

The MYND domain was named based on the first three proteins that were found to contain this region: myeloid translocation protein 8, Nervy, and DEAF-1. There are now more than 80 proteins known to contain the MYND domain.

Which genes are included in the ZMYND gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the ZMYND family (http://www.genenames.org/genefamily/zmynd.php).

Genetics Home Reference summarizes the normal function and health implications of these members of the ZMYND gene family: EGLN1 and RUNX1T1.

What conditions are related to genes in the ZMYND gene family?

Genetics Home Reference includes these conditions related to genes in the ZMYND gene family:

  • core binding factor acute myeloid leukemia
  • familial erythrocytosis

Where can I find additional information about the ZMYND gene family?

You may find the following resources about the ZMYND gene family helpful.

  • InterPro: Zinc Finger, MYND-type (http://www.ebi.ac.uk/interpro/entry/IPR002893)
  • Molecular Cell Biology (fourth edition, 2000): Zinc Finger Proteins (http://www.ncbi.nlm.nih.gov/books/NBK21572/)
  • RCSB Protein Data Bank: Zinc Fingers (http://www.rcsb.org/pdb/101/motm.do?momID=87)

What glossary definitions help with understanding the ZMYND gene family?

acids ; amino acid ; DNA ; domain ; gene ; histidine ; hypoxia ; ions ; myeloid ; protein ; transcription ; transcription factor ; translocation

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

These sources were used to develop the Genetics Home Reference summary for the ZMYND gene family.

  • Matthews JM, Bhati M, Lehtomaki E, Mansfield RE, Cubeddu L, Mackay JP. It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains. Curr Pharm Des. 2009;15(31):3681-96. Review. (http://www.ncbi.nlm.nih.gov/pubmed/19925420?dopt=Abstract)
  • Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH. Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell. 2007 Jun;11(6):483-97. (http://www.ncbi.nlm.nih.gov/pubmed/17560331?dopt=Abstract)
  • Gross CT, McGinnis W. DEAF-1, a novel protein that binds an essential region in a Deformed response element. EMBO J. 1996 Apr 15;15(8):1961-70. (http://www.ncbi.nlm.nih.gov/pubmed/8617243?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: August 2012
Published: November 17, 2014