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Comparative genomic hybridization

Synonym(s)

  • CGH
  • comparative genome hybridization
  • comparative genomic analysis

Definition(s)

Comparative genomic hybridization (CGH) is a technique that allows the detection of losses and gains in DNA copy number across the entire genome without prior knowledge of specific chromosomal abnormalities. Comparative genomic hybridization utilizes the hybridization of differentially labeled tumor and reference DNA to generate a map of DNA copy number changes in tumor genomes. Comparative genomic hybridization is an ideal tool for analyzing chromosomal imbalances in archived tumor material and for examining possible correlations between these findings and tumor phenotypes.

Definition from: NCI Thesaurus via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Technique which produces a map of DNA sequence copy number as a function of chromosomal location throughout the entire genetic genome, and allows the detection of genetic deletions, duplications, and amplifications.

Definition from: CRISP Thesaurus via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

See also Understanding Medical Terminology.

 
Published: July 7, 2014