Skip Navigation
Genetics Home Reference: your guide to understanding genetic conditions About   Site Map   Contact Us
 
Home A service of the U.S. National Library of Medicine®
0-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q-R | S | T | U | V | W | X | Y-Z

Creatine kinase

Synonym(s)

  • ATP creatine phosphotransferase
  • CPK
  • creatine kinase (CK)
  • creatine kinase (substance)
  • creatine phosphokinase

Definition(s)

A transferase that catalyzes formation of phosphocreatine from ATP + creatine. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: the MM type from skeletal muscle, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.

Definition from: MeSH via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Encoded by human CKB Gene (ATP:Guanido Phosphotransferase Family), 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase is a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.

Definition from: NCI via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

See also Understanding Medical Terminology.

 
Published: November 17, 2014