The exchange of a segment of DNA between two homologous chromosomes
during meiosis leading to a novel combination of genetic material in the
offspring
Definition from: GeneTests
from the University of Washington and Children's Health System, Seattle
Crossing over is the swapping of genetic material that occurs in the germ line. During the formation of egg and sperm cells, also known as meiosis, paired chromosomes from each parent align so that similar DNA sequences from the paired chromosomes cross over one another. Crossing over results in a shuffling of genetic material and is an important cause of the genetic variation seen among offspring.