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Dominant negative mutation

Definition(s)

A mutation whose gene product adversely affects the normal, wild-type gene product within the same cell, usually by dimerizing (combining) with it. In cases of polymeric molecules, such as collagen, dominant negative mutations are often more deleterious than mutations causing the production of no gene product (null mutations or null alleles).: Definition from: GeneReviews from the University of Washington and the National Center for Biotechnology Information


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