Skip Navigation
Genetics Home Reference: your guide to understanding genetic conditions About   Site Map   Contact Us
 
Home A service of the U.S. National Library of Medicine®
0-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q-R | S | T | U | V | W | X | Y-Z

Dosage analysis

Definition(s)

Method of measuring the quantity of a variety of analytes, including DNA, RNA, and protein, by comparison with a known standard; can be used to determine the number of copies of a sequence of DNA (i.e., to test for duplication and deletion mutations) either by visual comparison of band intensity or numerical quantification by densitometry. If extra copies of a gene are present, intensity is greater than 100% on a gel or film; whereas, if one copy of the gene is missing, the intensity is approximately 50%.

Definition from: GeneReviewsThis link leads to a site outside Genetics Home Reference. from the University of Washington and the National Center for Biotechnology Information

See also Understanding Medical Terminology.

 
Published: December 16, 2014