Definition(s)
- The
process by which certain exons (coding regions within a gene), under highest
suspicion to contain a specific mutation, are subjected to testing via conformation
sensitive gel electrophoresis (CSGE), single-stranded conformational-polymorphism
(SSCP), denaturing gradient gel electrophoresis (DGGE), or other means deemed
most appropriate, to confirm the presence of a mutation before use of further
testing, such as sequencing, to delineate the exact nature of the mutation;
used to expedite analysis when the disorder in question can be caused by
numerous possible mutations within a gene
-
Definition from: GeneReviews
from the University of Washington and the National Center for Biotechnology Information
See also Understanding Medical Terminology.
