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Fibrinogen

Synonym(s)

  • blood coagulation factor I
  • coagulation factor I
  • factor I

Definition(s)

A fibrillar protein present in blood plasma; it converts to fibrin during the process of blood clot formation.

Definition from: NCI via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

Definition from: MeSH via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

See also Understanding Medical Terminology.

 
Published: December 16, 2014