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Fusion gene

Definition(s)

A gene made by joining parts of two different genes. Fusion genes may occur naturally in the body by transfer of DNA between chromosomes. For example, the BCR-ABL gene found in some types of leukemia is a fusion gene. Fusion genes can also be made in the laboratory by combining genes or parts of genes from the same or different organisms.

Definition from: NCI via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

A hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or regulate gene transcription). These can be created by chromosomal aberration or by laboratory methods.

Definition from: NCI via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Related discussion in the Handbook

See also Understanding Medical Terminology.

 
Published: August 25, 2014