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Genome-wide association study

Synonym(s)

  • genome wide association scan
  • GWA
  • GWAS
  • GWA study
  • whole genome association analysis
  • whole genome association study

Definition(s)

Genome-wide association studies (GWAS) are a way for scientists to identify genes involved in human disease. This method searches the genome for small variations, called single nucleotide polymorphisms or SNPs (pronounced "snips"), that occur more frequently in people with a particular disease than in people without the disease.

Definition from: NCI Thesaurus via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

An analysis comparing the allele frequencies of all available (or a whole genome representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.

Definition from: MeSH via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Related discussion in the Handbook

See also Understanding Medical Terminology.

 
Published: November 17, 2014