of mutation detection by which proteins are separated according to the pH
at which their net charge is zero (isoelectric point); often used in conjunction
with a western blot to allow identification of wild-type versus mutant protein
products. A DNA sequence alteration resulting in an amino acid substitution
can change the isoelectric point of a protein.
Definition from: GeneReviews
from the University of Washington and the National Center for Biotechnology Information
See also Understanding Medical Terminology.