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Linkage analysis

Synonym(s)

The use of several DNA sequence polymorphisms (normal variants) that are near or within a gene of interest to track within a family the inheritance of a disease-causing mutation in that gene: Definition from: GeneReviews from the University of Washington and the National Center for Biotechnology Information
A gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits that are co-inherited with it.: Definition from: Office of Rare Diseases at the National Institutes of Health


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