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Loss of heterozygosity

Definition(s)

(LOH) At a particular locus heterozygous for a deleterious mutant allele and a normal allele, a deletion or other mutational event within the normal allele renders the cell either hemizygous (one deleterious allele and one deleted allele) or homozygous for the deleterious allele: Definition from: GeneReviews from the University of Washington and the National Center for Biotechnology Information


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