identifiable segment of DNA (e.g., RFLP, VNTR, microsatellite) with enough
variation between individuals that its inheritance and co-inheritance with
alleles of a given gene can be traced; used in linkage analysis
Definition from: GeneReviews
from the University of Washington and the National Center for Biotechnology Information
- A marker is a DNA sequence with a known physical location on a chromosome. Markers can help link an inherited disease with the responsible genes. DNA segments close to each other on a chromosome tend to be inherited together. Markers are used to track the inheritance of a nearby gene that has not yet been identified but whose approximate location is known. The marker itself may be a part of a gene or may have no known function.
Definition from: Talking Glossary of Genetic Terms from the National Human Genome Research Institute
Related discussion in the Handbook
See also Understanding Medical Terminology.