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Open reading frame

Synonym(s)

  • ORFs
  • protein coding sequences

Definition(s)

A reading frame in a sequence of nucleotides in DNA that contains no termination codons and so can potentially translate as a polypeptide chain.

Definition from: NCI Thesaurus via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

A reading frame that does not contain a nucleotide triplet which stops translation before formation of a complete polypeptide -- abbreviation ORF.

Definition from: Merriam-Webster's Medical DictionaryThis link leads to a site outside Genetics Home Reference. by Merriam-Webster Inc.

An open reading frame is a portion of a DNA molecule that, when translated into amino acids, contains no stop codons. The genetic code reads DNA sequences in groups of three base pairs, which means that a double-stranded DNA molecule can read in any of six possible reading frames--three in the forward direction and three in the reverse. A long open reading frame is likely part of a gene.

Definition from: Talking Glossary of Genetic TermsThis link leads to a site outside Genetics Home Reference. from the National Human Genome Research Institute

Related discussion in the Handbook

See also Understanding Medical Terminology.

 
Published: October 20, 2014