- Short tracts of DNA sequence that are used as landmarks in genome mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.
Definition from: MeSH via Unified Medical Language System at the National Library of Medicine
- Short, single-copy, genomic DNA sequences spaced at intervals of about 100 kb, used as landmarks to identify the physical origin (chromosomal position) of any clone (gene) of interest; touted as the new "lingua franca" of genome mapping.
Definition from: CRISP Thesaurus via Unified Medical Language System at the National Library of Medicine
Related discussion in the Handbook
See also Understanding Medical Terminology.